| Player | Team | AB | TB | SLG |
|---|---|---|---|---|
| Marcell Ozuna | Orlando | 594 | 443 | 0.746 |
| Brandon Belt | Oak Lawn | 435 | 280 | 0.644 |
| Jose Abreu | Oak Lawn | 647 | 412 | 0.637 |
| Luke Voit | Milwaukee | 604 | 367 | 0.608 |
| Peter Alonso | Niagara Falls | 525 | 312 | 0.594 |
| Fernando Tatis Jr | Elko | 642 | 379 | 0.590 |
| Juan Soto | Oak Lawn | 444 | 262 | 0.590 |
| Manny Machado | Wisc. Rapids | 644 | 376 | 0.584 |
| Trea Turner | Wisc. Rapids | 689 | 391 | 0.567 |
| Mike Trout | Peculiar | 598 | 337 | 0.564 |
| Michael Conforto | Peculiar | 603 | 333 | 0.552 |
| Jesse Winker | Phoenix | 431 | 238 | 0.552 |
| Mookie Betts | Burlington | 472 | 260 | 0.551 |
| Gio Urshela | Phoenix | 467 | 257 | 0.550 |
| Renato Nunez | Phoenix | 527 | 290 | 0.550 |
| DJ LeMahieu | Phoenix | 548 | 300 | 0.547 |
| Eloy Jimenez | Orlando | 639 | 348 | 0.545 |
| Mike Yastrzemski | Niagara Falls | 565 | 306 | 0.542 |
| Corey Seager | Burlington | 628 | 336 | 0.535 |
| George Springer | Detroit | 544 | 291 | 0.535 |