| Player | Team | AB | TB | SLG |
|---|---|---|---|---|
| Dominic Smith | Montana | 494 | 341 | 0.690 |
| Freddie Freeman | Foscoe | 566 | 379 | 0.670 |
| Manny Machado | Brooklyn | 678 | 440 | 0.649 |
| Juan Soto | Brooklyn | 445 | 278 | 0.625 |
| Travis d'Arnaud | Colorado | 488 | 296 | 0.607 |
| Luke Voit | Kansas City | 614 | 365 | 0.594 |
| Jose Ramirez | Foscoe | 593 | 349 | 0.589 |
| Ronald Acuna | Fraser | 465 | 267 | 0.574 |
| Wilmer Flores | Southland | 581 | 327 | 0.563 |
| Michael Conforto | Southland | 592 | 327 | 0.552 |
| Trevor Story | Montana | 682 | 374 | 0.548 |
| Robbie Grossman | Colorado | 496 | 266 | 0.536 |
| Mike Yastrzemski | Colorado | 544 | 290 | 0.533 |
| Evan Longoria | Southland | 549 | 291 | 0.530 |
| Eloy Jimenez | Brooklyn | 626 | 329 | 0.526 |
| Eddie Rosario | Chicago | 494 | 258 | 0.522 |
| Chris Taylor | Montana | 506 | 264 | 0.522 |
| Brandon Nimmo | Brooklyn | 460 | 240 | 0.522 |
| Jesse Winker | Fraser | 421 | 216 | 0.513 |
| Corey Seager | Foscoe | 626 | 318 | 0.508 |