| Player | Team | AB | TB | SLG |
|---|---|---|---|---|
| Juan Soto | Syracuse | 404 | 281 | 0.696 |
| Wil Myers | Jacksonville | 522 | 331 | 0.634 |
| Mike Trout | Riverside | 585 | 364 | 0.622 |
| Freddie Freeman | Las Vegas | 450 | 275 | 0.611 |
| Manny Machado | Havana | 632 | 383 | 0.606 |
| Teoscar Hernandez | Guildford | 572 | 345 | 0.603 |
| Jose Ramirez | Albuquerque | 604 | 364 | 0.603 |
| DJ LeMahieu | Tampa | 554 | 332 | 0.599 |
| George Springer | Gallup | 569 | 335 | 0.589 |
| Wilmer Flores | New Jersey | 529 | 311 | 0.588 |
| Kyle Tucker | Havana | 504 | 294 | 0.583 |
| Marcell Ozuna | Guildford | 640 | 366 | 0.572 |
| Jose Abreu | Boston | 665 | 376 | 0.565 |
| Mike Yastrzemski | Albuquerque | 527 | 295 | 0.560 |
| A.J. Pollock | Jacksonville | 568 | 317 | 0.558 |
| Travis d'Arnaud | Orlando | 491 | 271 | 0.552 |
| Trea Turner | Sterling | 639 | 350 | 0.548 |
| Xander Bogaerts | Gallup | 566 | 309 | 0.546 |
| Brandon Nimmo | Boston | 423 | 230 | 0.544 |
| Dominic Smith | Las Vegas | 524 | 281 | 0.536 |