| Player | Team | AB | TB | SLG |
|---|---|---|---|---|
| Marcell Ozuna | Orlando | 594 | 443 | 0.746 |
| Peter Alonso | Niagara Falls | 525 | 312 | 0.594 |
| Jesse Winker | Phoenix | 431 | 238 | 0.552 |
| Mookie Betts | Burlington | 472 | 260 | 0.551 |
| Gio Urshela | Phoenix | 467 | 257 | 0.550 |
| Renato Nunez | Phoenix | 527 | 290 | 0.550 |
| DJ LeMahieu | Phoenix | 548 | 300 | 0.547 |
| Eloy Jimenez | Orlando | 639 | 348 | 0.545 |
| Mike Yastrzemski | Niagara Falls | 565 | 306 | 0.542 |
| Corey Seager | Burlington | 628 | 336 | 0.535 |
| George Springer | Detroit | 544 | 291 | 0.535 |
| Jake Cronenworth | Clinton | 479 | 254 | 0.530 |
| Wilmer Flores | Niagara Falls | 567 | 298 | 0.526 |
| Colin Moran | Connecticut | 532 | 278 | 0.523 |
| Trent Grisham | Phoenix | 577 | 298 | 0.516 |
| Jeff McNeil | Clinton | 538 | 275 | 0.511 |
| Robinson Cano | Orlando | 507 | 259 | 0.511 |
| Adam Duvall | Phoenix | 559 | 280 | 0.501 |
| A.J. Pollock | Connecticut | 567 | 281 | 0.496 |
| J.T. Realmuto | Niagara Falls | 481 | 237 | 0.493 |