| Player | Team | IP | ERA |
|---|---|---|---|
| Dinelson Lamet | Clinton | 208.1 | 1.43 |
| Brad Keller | Elko | 163 | 1.60 |
| Cole Hamels | Clinton | 217.2 | 1.90 |
| Corbin Burnes | Elko | 166 | 2.06 |
| Shane Bieber | Peculiar | 231.2 | 2.14 |
| Kenta Maeda | Monet | 203.1 | 2.35 |
| Dallas Keuchel | Oak Lawn | 167.1 | 2.37 |
| Jacob deGrom | Huntington Beach | 180.1 | 2.40 |
| Dylan Bundy | Milwaukee | 170 | 2.65 |
| Yu Darvish | Torrance Beach | 198 | 2.73 |
| Carlos Carrasco | Peculiar | 202.1 | 2.76 |
| Marco Gonzales | Orlando | 219 | 2.96 |
| Trevor Bauer | Peculiar | 210.1 | 3.12 |
| Zach Davies | Clinton | 204 | 3.22 |
| Brady Singer | Orlando | 201 | 3.31 |
| Brandon Woodruff | Dayton | 225 | 3.32 |
| Framber Valdez | Brooklyn | 205 | 3.34 |
| Zac Gallen | Torrance Beach | 193.2 | 3.35 |
| Kyle Hendricks | Connecticut | 241 | 3.44 |
| Adam Wainwright | Brooklyn | 152.2 | 3.48 |