| Player | Team | IP | ERA |
|---|---|---|---|
| Shane Bieber | Kankakee | 241.1 | 2.13 |
| Dinelson Lamet | Fraser | 207.1 | 2.17 |
| Yu Darvish | Boise | 231.2 | 2.41 |
| Kenta Maeda | Fraser | 196 | 2.43 |
| Zach Davies | Kansas City | 200 | 2.70 |
| Trevor Bauer | Ohio | 210 | 2.79 |
| Chris Bassitt | Dakota | 164.2 | 3.06 |
| Lance McCullers | Arizona | 162.1 | 3.10 |
| Jacob deGrom | Arizona | 212.2 | 3.13 |
| Lucas Giolito | Chicago | 217 | 3.28 |
| Dallas Keuchel | South Iowa | 197.2 | 3.28 |
| Zach Plesac | South Iowa | 169 | 3.36 |
| Carlos Carrasco | Foscoe | 196.1 | 3.39 |
| Brandon Woodruff | Portland | 226.1 | 3.42 |
| Dylan Bundy | Kansas City | 203 | 3.50 |
| Brad Wieck | Fraser | 39.1 | 3.66 |
| Zack Greinke | Albuquerque | 188.2 | 3.67 |
| Adam Wainwright | Montana | 200.1 | 3.73 |
| Aaron Nola | Portland | 221.1 | 3.74 |
| Kevin Gausman | Kankakee | 170 | 3.81 |