| Player | Team | IP | ERA |
|---|---|---|---|
| Dinelson Lamet | Sterling | 211 | 1.83 |
| Zach Plesac | Sterling | 159.1 | 1.86 |
| Max Fried | New Jersey | 170.2 | 1.95 |
| Jacob deGrom | Sterling | 202.2 | 2.13 |
| Lucas Giolito | Las Vegas | 191 | 2.36 |
| Kenta Maeda | Kansas City | 198.1 | 2.50 |
| Trevor Bauer | Havana | 198 | 2.55 |
| Dallas Keuchel | California | 193 | 2.70 |
| Shane Bieber | Jacksonville | 206 | 2.71 |
| Dylan Bundy | St. Louis | 208 | 2.81 |
| Pablo Lopez | New York | 173.1 | 2.91 |
| Yu Darvish | Kansas City | 225.2 | 2.95 |
| Lance McCullers | Guildford | 173.1 | 2.96 |
| Corbin Burnes | Jacksonville | 175 | 3.24 |
| Hyun Jin Ryu | Havana | 195.2 | 3.31 |
| Aaron Nola | Sterling | 218.2 | 3.38 |
| Kyle Hendricks | Kansas City | 231.1 | 3.42 |
| Spencer Turnbull | California | 174.1 | 3.46 |
| Luis Castillo | Havana | 200.2 | 3.50 |
| Zach Davies | Albuquerque | 180.2 | 3.54 |