| Player | Team | IP | ERA |
|---|---|---|---|
| Brad Keller | Elko | 163 | 1.60 |
| Corbin Burnes | Elko | 166 | 2.06 |
| Shane Bieber | Peculiar | 231.2 | 2.14 |
| Kenta Maeda | Monet | 203.1 | 2.35 |
| Dallas Keuchel | Oak Lawn | 167.1 | 2.37 |
| Dylan Bundy | Milwaukee | 170 | 2.65 |
| Carlos Carrasco | Peculiar | 202.1 | 2.76 |
| Trevor Bauer | Peculiar | 210.1 | 3.12 |
| Brandon Woodruff | Dayton | 225 | 3.32 |
| Framber Valdez | Brooklyn | 205 | 3.34 |
| Adam Wainwright | Brooklyn | 152.2 | 3.48 |
| Sonny Gray | Peculiar | 160 | 3.49 |
| Lance Lynn | Brooklyn | 228.2 | 3.62 |
| Lucas Giolito | Elko | 171.2 | 3.77 |
| Hyun Jin Ryu | Wisc. Rapids | 184.1 | 3.91 |
| Johnny Cueto | Milwaukee | 175.1 | 4.16 |
| Chris Bassitt | Chicago | 186.1 | 4.20 |
| Zack Wheeler | Brooklyn | 214.2 | 4.32 |
| Tyler Anderson | Monet | 177.2 | 4.46 |
| Zach Eflin | Chicago | 173.1 | 4.67 |