| Player | Team | IP | ERA |
|---|---|---|---|
| Dinelson Lamet | Clinton | 208.1 | 1.43 |
| Cole Hamels | Clinton | 217.2 | 1.90 |
| Jacob deGrom | Huntington Beach | 180.1 | 2.40 |
| Yu Darvish | Torrance Beach | 198 | 2.73 |
| Marco Gonzales | Orlando | 219 | 2.96 |
| Zach Davies | Clinton | 204 | 3.22 |
| Brady Singer | Orlando | 201 | 3.31 |
| Zac Gallen | Torrance Beach | 193.2 | 3.35 |
| Kyle Hendricks | Connecticut | 241 | 3.44 |
| Cristian Javier | Orlando | 165.1 | 3.54 |
| Clayton Kershaw | Connecticut | 166.2 | 3.56 |
| Gerrit Cole | Burlington | 220.1 | 3.68 |
| Spencer Turnbull | Niagara Falls | 171.2 | 3.93 |
| Jesus Luzardo | Huntington Beach | 167.1 | 4.46 |
| Max Scherzer | Clinton | 183.1 | 4.81 |
| German Marquez | Clinton | 244 | 4.83 |
| Chris Paddack | Huntington Beach | 160 | 4.84 |
| Aaron Nola | Burlington | 215.2 | 4.84 |
| Rick Porcello | Phoenix | 205 | 4.92 |
| Seth Lugo | Amarillo | 196.2 | 5.63 |