| Player | Team | IP | ERA |
|---|---|---|---|
| Shane Bieber | Peculiar | 231.2 | 2.14 |
| Dylan Bundy | Milwaukee | 170 | 2.65 |
| Carlos Carrasco | Peculiar | 202.1 | 2.76 |
| Trevor Bauer | Peculiar | 210.1 | 3.12 |
| Sonny Gray | Peculiar | 160 | 3.49 |
| Hyun Jin Ryu | Wisc. Rapids | 184.1 | 3.91 |
| Johnny Cueto | Milwaukee | 175.1 | 4.16 |
| Chris Bassitt | Chicago | 186.1 | 4.20 |
| Zach Eflin | Chicago | 173.1 | 4.67 |
| Adrian Houser | Chicago | 165 | 4.75 |
| Zack Greinke | Wisc. Rapids | 195.1 | 4.93 |
| Ryan Yarbrough | El Paso | 169.2 | 4.93 |
| Antonio Senzatela | El Paso | 210.1 | 4.96 |
| Martin Perez | Chicago | 182.2 | 5.12 |
| Mike Fiers | Chicago | 169 | 5.22 |
| Aaron Civale | El Paso | 189.1 | 5.23 |
| Frankie Montas | Wisc. Rapids | 186.1 | 7.25 |
| Anibal Sanchez | Wisc. Rapids | 182.1 | 7.85 |