| Player | Team | SO |
|---|---|---|
| Miguel Sano | Tampa | 253 |
| Luis Robert | Chicago | 247 |
| Willy Adames | Las Vegas | 244 |
| Kyle Lewis | Las Vegas | 239 |
| Garrett Hampson | St. Louis | 238 |
| Edward Olivares | Syracuse | 235 |
| Teoscar Hernandez | Guildford | 233 |
| Trevor Story | Syracuse | 226 |
| Franmil Reyes | Manhattan | 226 |
| Mike Zunino | Manhattan | 226 |
| Rafael Devers | Malibu | 225 |
| Christian Yelich | Jacksonville | 220 |
| Brian Anderson | Guildford | 212 |
| Dansby Swanson | Manhattan | 209 |
| Mark Canha | Guildford | 203 |
| Marcell Ozuna | Guildford | 202 |
| Yoan Moncada | Tampa | 202 |
| Eugenio Suarez | Kansas City | 195 |
| Cavan Biggio | Boston | 192 |
| Christian Walker | Orlando | 186 |