| Player | Team | 2B |
|---|---|---|
| Dominic Smith | Las Vegas | 52 |
| Jose Abreu | Boston | 50 |
| Jake Cronenworth | Sterling | 50 |
| Trea Turner | Sterling | 47 |
| Christian Walker | Orlando | 47 |
| Freddie Freeman | Las Vegas | 45 |
| Donovan Solano | Riverside | 44 |
| Kyle Tucker | Havana | 44 |
| Michael Brantley | California | 43 |
| Jose Ramirez | Albuquerque | 43 |
| Rafael Devers | Malibu | 42 |
| Kyle Seager | Syracuse | 42 |
| Jose Iglesias | Las Vegas | 42 |
| Starling Marte | New Jersey | 41 |
| Manny Machado | Havana | 41 |
| Willy Adames | Las Vegas | 39 |
| Cesar Hernandez | California | 38 |
| Justin Turner | Sterling | 37 |
| Jeff McNeil | Tampa | 37 |
| Gio Urshela | New York | 36 |