| Player | Team | RBI |
|---|---|---|
| Marcell Ozuna | Orlando | 168 |
| Fernando Tatis Jr | Elko | 156 |
| Manny Machado | Wisc. Rapids | 146 |
| Jose Abreu | Oak Lawn | 137 |
| Mike Yastrzemski | Niagara Falls | 126 |
| Peter Alonso | Niagara Falls | 126 |
| Mike Trout | Peculiar | 124 |
| Luke Voit | Milwaukee | 119 |
| Renato Nunez | Phoenix | 119 |
| Eloy Jimenez | Orlando | 115 |
| Adam Duvall | Phoenix | 108 |
| A.J. Pollock | Connecticut | 108 |
| Trevor Story | Phoenix | 108 |
| George Springer | Detroit | 107 |
| Trea Turner | Wisc. Rapids | 106 |
| Byron Buxton | Clinton | 105 |
| Michael Conforto | Peculiar | 104 |
| Wilmer Flores | Niagara Falls | 104 |
| Salvador Perez | Milwaukee | 102 |
| Gio Urshela | Phoenix | 101 |