| Player | Team | SO |
|---|---|---|
| Miguel Sano | Brooklyn | 250 |
| Garrett Hampson | Detroit | 238 |
| Trevor Story | Phoenix | 223 |
| Ryan McMahon | Huntington Beach | 218 |
| Luis Robert | Oak Lawn | 217 |
| Rougned Odor | Peculiar | 216 |
| Matt Olson | Peculiar | 216 |
| Yoan Moncada | Elko | 210 |
| Mike Zunino | Brooklyn | 206 |
| Ramon Laureano | Orlando | 201 |
| Renato Nunez | Phoenix | 200 |
| Christian Yelich | Huntington Beach | 193 |
| Franmil Reyes | Brooklyn | 193 |
| Mike Trout | Peculiar | 193 |
| Cavan Biggio | Connecticut | 192 |
| Jake Cave | Amarillo | 189 |
| Fernando Tatis Jr | Elko | 187 |
| Dansby Swanson | Brooklyn | 187 |
| Eloy Jimenez | Orlando | 183 |
| Javier Baez | El Paso | 182 |