| Player | Team | 2B |
|---|---|---|
| Jake Cronenworth | Clinton | 49 |
| Cesar Hernandez | Elko | 48 |
| Jose Iglesias | Amarillo | 48 |
| Jeff McNeil | Clinton | 46 |
| Marcell Ozuna | Orlando | 44 |
| Christian Walker | Burlington | 44 |
| Nick Senzel | Huntington Beach | 44 |
| Alex Verdugo | Detroit | 42 |
| Hanser Alberto | Monet | 42 |
| Gio Urshela | Phoenix | 41 |
| Eloy Jimenez | Orlando | 40 |
| Maikel Franco | Clinton | 40 |
| Freddie Freeman | Dayton | 40 |
| Chris Taylor | Elko | 39 |
| Francisco Lindor | Milwaukee | 38 |
| Jose Abreu | Oak Lawn | 37 |
| Starling Marte | Detroit | 37 |
| Cavan Biggio | Connecticut | 37 |
| Charlie Blackmon | Monet | 36 |
| Michael Conforto | Peculiar | 36 |