| Player | Team | HR |
|---|---|---|
| Marcell Ozuna | Orlando | 64 |
| Fernando Tatis Jr | Elko | 58 |
| Luke Voit | Milwaukee | 58 |
| Jose Abreu | Oak Lawn | 57 |
| Mike Trout | Peculiar | 49 |
| Manny Machado | Wisc. Rapids | 49 |
| Rougned Odor | Peculiar | 48 |
| Adam Duvall | Phoenix | 45 |
| Peter Alonso | Niagara Falls | 45 |
| Corey Seager | Burlington | 44 |
| A.J. Pollock | Connecticut | 44 |
| Byron Buxton | Clinton | 43 |
| Eloy Jimenez | Orlando | 42 |
| Colin Moran | Connecticut | 40 |
| Renato Nunez | Phoenix | 40 |
| Jesse Winker | Phoenix | 40 |
| J.T. Realmuto | Niagara Falls | 38 |
| Wilmer Flores | Niagara Falls | 38 |
| George Springer | Detroit | 38 |
| Matt Olson | Peculiar | 37 |