| Player | Team | RBI |
|---|---|---|
| Mike Trout | Riverside | 141 |
| Manny Machado | Havana | 138 |
| Trea Turner | Sterling | 129 |
| Jose Ramirez | Albuquerque | 126 |
| Wil Myers | Jacksonville | 125 |
| Teoscar Hernandez | Guildford | 124 |
| A.J. Pollock | Jacksonville | 121 |
| Marcell Ozuna | Guildford | 108 |
| Edward Olivares | Syracuse | 105 |
| Juan Soto | Syracuse | 100 |
| Jake Cronenworth | Sterling | 99 |
| Didi Gregorius | Riverside | 98 |
| Christian Walker | Orlando | 93 |
| Tim Anderson | Malibu | 92 |
| Bryce Harper | Malibu | 90 |
| Kyle Seager | Syracuse | 90 |
| Mike Yastrzemski | Albuquerque | 89 |
| Nicholas Castellanos | Albuquerque | 89 |
| Rafael Devers | Malibu | 88 |
| Kyle Tucker | Havana | 85 |