| Player | Team | SO |
|---|---|---|
| Luis Robert | Chicago | 247 |
| Edward Olivares | Syracuse | 235 |
| Teoscar Hernandez | Guildford | 233 |
| Trevor Story | Syracuse | 226 |
| Rafael Devers | Malibu | 225 |
| Christian Yelich | Jacksonville | 220 |
| Brian Anderson | Guildford | 212 |
| Mark Canha | Guildford | 203 |
| Marcell Ozuna | Guildford | 202 |
| Christian Walker | Orlando | 186 |
| Yasmani Grandal | Malibu | 184 |
| Travis d'Arnaud | Orlando | 179 |
| Jackie Bradley | Guildford | 175 |
| Myles Straw | Orlando | 174 |
| Wil Myers | Jacksonville | 172 |
| Tommy Edman | Havana | 165 |
| Matt Chapman | Orlando | 162 |
| Mike Trout | Riverside | 161 |
| Ian Happ | Chicago | 159 |
| Alex Verdugo | Havana | 158 |