| Player | Team | RBI |
|---|---|---|
| Marcell Ozuna | Orlando | 168 |
| Mike Yastrzemski | Niagara Falls | 126 |
| Peter Alonso | Niagara Falls | 126 |
| Renato Nunez | Phoenix | 119 |
| Eloy Jimenez | Orlando | 115 |
| Adam Duvall | Phoenix | 108 |
| A.J. Pollock | Connecticut | 108 |
| Trevor Story | Phoenix | 108 |
| George Springer | Detroit | 107 |
| Byron Buxton | Clinton | 105 |
| Wilmer Flores | Niagara Falls | 104 |
| Gio Urshela | Phoenix | 101 |
| Trent Grisham | Phoenix | 101 |
| Mookie Betts | Burlington | 97 |
| Jesse Winker | Phoenix | 97 |
| Corey Seager | Burlington | 94 |
| J.T. Realmuto | Niagara Falls | 93 |
| Robinson Cano | Orlando | 90 |
| Maikel Franco | Clinton | 88 |
| DJ LeMahieu | Phoenix | 87 |