| Player | Team | HR |
|---|---|---|
| Marcell Ozuna | Orlando | 64 |
| Adam Duvall | Phoenix | 45 |
| Peter Alonso | Niagara Falls | 45 |
| Corey Seager | Burlington | 44 |
| A.J. Pollock | Connecticut | 44 |
| Byron Buxton | Clinton | 43 |
| Eloy Jimenez | Orlando | 42 |
| Colin Moran | Connecticut | 40 |
| Renato Nunez | Phoenix | 40 |
| Jesse Winker | Phoenix | 40 |
| J.T. Realmuto | Niagara Falls | 38 |
| Wilmer Flores | Niagara Falls | 38 |
| George Springer | Detroit | 38 |
| Mookie Betts | Burlington | 34 |
| Trent Grisham | Phoenix | 34 |
| Randal Grichuk | Clinton | 33 |
| Travis d'Arnaud | Orlando | 32 |
| Trevor Story | Phoenix | 32 |
| Mike Yastrzemski | Niagara Falls | 32 |
| Mitch Moreland | Amarillo | 31 |