| Player | Team | RBI |
|---|---|---|
| Manny Machado | Brooklyn | 167 |
| Fernando Tatis Jr | Ohio | 155 |
| Mike Trout | Albuquerque | 147 |
| Nelson Cruz | Albuquerque | 132 |
| Luke Voit | Kansas City | 132 |
| Marcell Ozuna | Orlando | 124 |
| Lourdes Gurriel Jr. | Montana | 122 |
| Eloy Jimenez | Brooklyn | 118 |
| Trevor Story | Montana | 116 |
| Jose Ramirez | Foscoe | 115 |
| Dominic Smith | Montana | 113 |
| Peter Alonso | Pea Ridge | 107 |
| Robinson Cano | Boise | 107 |
| Anthony Rizzo | Colorado | 107 |
| Luis Robert | South Iowa | 106 |
| Trea Turner | South Iowa | 105 |
| Alex Dickerson | Boise | 104 |
| Jose Abreu | Orlando | 104 |
| Juan Soto | Brooklyn | 103 |
| Didi Gregorius | Arizona | 103 |