| Player | Team | SO |
|---|---|---|
| Willy Adames | Chicago | 251 |
| Franmil Reyes | Southland | 239 |
| Luis Robert | South Iowa | 235 |
| Javier Baez | Foscoe | 227 |
| Garrett Hampson | Montana | 224 |
| Yoan Moncada | Portland | 223 |
| Dansby Swanson | Boise | 223 |
| Matt Carpenter | Tacoma | 219 |
| Christian Yelich | Arizona | 214 |
| Ian Happ | Chicago | 210 |
| Matt Olson | Ohio | 210 |
| Peter Alonso | Pea Ridge | 209 |
| Eugenio Suarez | Arizona | 208 |
| Aristides Aquino | Tacoma | 204 |
| Brandon Lowe | Kansas City | 204 |
| Teoscar Hernandez | Herefordshire | 201 |
| Renato Nunez | Herefordshire | 198 |
| Trevor Story | Montana | 198 |
| Cavan Biggio | Dakota | 197 |
| Mike Yastrzemski | Colorado | 194 |