| Player | Team | HR |
|---|---|---|
| Luke Voit | Kansas City | 61 |
| Fernando Tatis Jr | Ohio | 60 |
| Mike Trout | Albuquerque | 58 |
| Manny Machado | Brooklyn | 53 |
| Nelson Cruz | Albuquerque | 50 |
| Marcell Ozuna | Orlando | 49 |
| Wilmer Flores | Southland | 45 |
| Trevor Story | Montana | 42 |
| Evan Longoria | Southland | 40 |
| Jose Ramirez | Foscoe | 40 |
| Joey Votto | Kankakee | 40 |
| Bryce Harper | Albuquerque | 39 |
| Alex Dickerson | Boise | 39 |
| Kole Calhoun | Boise | 39 |
| Freddie Freeman | Foscoe | 39 |
| Ronald Acuna | Fraser | 39 |
| Anthony Rizzo | Colorado | 38 |
| George Springer | Kankakee | 38 |
| Salvador Perez | Foscoe | 37 |
| Eloy Jimenez | Brooklyn | 37 |