| Player | Team | SO |
|---|---|---|
| Miguel Sano | Tampa | 253 |
| Willy Adames | Las Vegas | 244 |
| Kyle Lewis | Las Vegas | 239 |
| Garrett Hampson | St. Louis | 238 |
| Franmil Reyes | Manhattan | 226 |
| Mike Zunino | Manhattan | 226 |
| Dansby Swanson | Manhattan | 209 |
| Yoan Moncada | Tampa | 202 |
| Eugenio Suarez | Kansas City | 195 |
| Cavan Biggio | Boston | 192 |
| Fernando Tatis Jr | Tampa | 185 |
| Monte Harrison | New York | 184 |
| Omar Narvaez | California | 182 |
| Eloy Jimenez | New York | 179 |
| Joey Bart | Boston | 177 |
| Austin Meadows | California | 176 |
| Cesar Hernandez | California | 175 |
| Ronald Acuna | St. Louis | 173 |
| Colin Moran | New Jersey | 171 |
| Michael Conforto | New Jersey | 170 |