| Player | Team | 2B |
|---|---|---|
| Jake Cronenworth | Sterling | 50 |
| Trea Turner | Sterling | 47 |
| Christian Walker | Orlando | 47 |
| Donovan Solano | Riverside | 44 |
| Kyle Tucker | Havana | 44 |
| Jose Ramirez | Albuquerque | 43 |
| Rafael Devers | Malibu | 42 |
| Kyle Seager | Syracuse | 42 |
| Manny Machado | Havana | 41 |
| Justin Turner | Sterling | 37 |
| Wil Myers | Jacksonville | 36 |
| Trevor Story | Syracuse | 36 |
| Mike Yastrzemski | Albuquerque | 36 |
| Juan Soto | Syracuse | 35 |
| Brandon Crawford | Guildford | 35 |
| Marcell Ozuna | Guildford | 35 |
| Tim Anderson | Malibu | 34 |
| Mike Tauchman | Syracuse | 33 |
| Myles Straw | Orlando | 32 |
| Aaron Hicks | Malibu | 31 |