| Player | Team | SO |
|---|---|---|
| Franmil Reyes | Manhattan | 226 |
| Mike Zunino | Manhattan | 226 |
| Dansby Swanson | Manhattan | 209 |
| Eugenio Suarez | Kansas City | 195 |
| Cavan Biggio | Boston | 192 |
| Monte Harrison | New York | 184 |
| Eloy Jimenez | New York | 179 |
| Joey Bart | Boston | 177 |
| Jose Abreu | Boston | 169 |
| Luke Voit | Kansas City | 166 |
| Dylan Carlson | Manhattan | 166 |
| Trent Grisham | Gallup | 160 |
| Willson Contreras | New York | 160 |
| Jose Marmolejos | Kansas City | 153 |
| Hunter Dozier | Manhattan | 152 |
| Andrew McCutchen | New York | 148 |
| Jean Segura | New York | 148 |
| Cody Bellinger | Boston | 135 |
| Nick Ahmed | Gallup | 133 |
| Pedro Severino | Kansas City | 132 |