| Player | Team | HR |
|---|---|---|
| Teoscar Hernandez | Guildford | 56 |
| Mike Trout | Riverside | 51 |
| Manny Machado | Havana | 50 |
| Jose Ramirez | Albuquerque | 50 |
| A.J. Pollock | Jacksonville | 48 |
| Luke Voit | Kansas City | 48 |
| George Springer | Gallup | 46 |
| Jose Abreu | Boston | 45 |
| Eddie Rosario | New Jersey | 45 |
| Marcell Ozuna | Guildford | 45 |
| Wilmer Flores | New Jersey | 42 |
| Wil Myers | Jacksonville | 41 |
| Ronald Acuna | St. Louis | 40 |
| Brian Anderson | Guildford | 38 |
| Fernando Tatis Jr | Tampa | 37 |
| Nicholas Castellanos | Albuquerque | 37 |
| Peter Alonso | Orlando | 35 |
| Max Muncy | Syracuse | 35 |
| Juan Soto | Syracuse | 35 |
| Xander Bogaerts | Gallup | 35 |