| Player | Team | SO |
|---|---|---|
| Miguel Sano | Brooklyn | 250 |
| Luis Robert | Oak Lawn | 217 |
| Rougned Odor | Peculiar | 216 |
| Matt Olson | Peculiar | 216 |
| Yoan Moncada | Elko | 210 |
| Mike Zunino | Brooklyn | 206 |
| Franmil Reyes | Brooklyn | 193 |
| Mike Trout | Peculiar | 193 |
| Fernando Tatis Jr | Elko | 187 |
| Dansby Swanson | Brooklyn | 187 |
| Javier Baez | El Paso | 182 |
| Kyle Lewis | Dayton | 181 |
| Ronald Acuna | El Paso | 180 |
| Michael Conforto | Peculiar | 180 |
| Jorge Soler | Monet | 178 |
| Matt Chapman | Dayton | 176 |
| Mark Canha | Dayton | 174 |
| Ian Happ | Chicago | 173 |
| Charlie Blackmon | Monet | 167 |
| Yasmani Grandal | Dayton | 166 |