| Player | Team | SO |
|---|---|---|
| Garrett Hampson | Detroit | 238 |
| Trevor Story | Phoenix | 223 |
| Ryan McMahon | Huntington Beach | 218 |
| Ramon Laureano | Orlando | 201 |
| Renato Nunez | Phoenix | 200 |
| Christian Yelich | Huntington Beach | 193 |
| Cavan Biggio | Connecticut | 192 |
| Jake Cave | Amarillo | 189 |
| Eloy Jimenez | Orlando | 183 |
| Adam Duvall | Phoenix | 176 |
| Teoscar Hernandez | Torrance Beach | 174 |
| Austin Meadows | Amarillo | 171 |
| Nicholas Castellanos | Connecticut | 170 |
| Trent Grisham | Phoenix | 169 |
| Mike Yastrzemski | Niagara Falls | 168 |
| Colin Moran | Connecticut | 168 |
| Randal Grichuk | Clinton | 167 |
| Paul DeJong | Connecticut | 166 |
| Rafael Devers | Torrance Beach | 166 |
| Christian Walker | Burlington | 165 |