| Player | Team | 2B |
|---|---|---|
| Jake Cronenworth | Clinton | 49 |
| Jose Iglesias | Amarillo | 48 |
| Jeff McNeil | Clinton | 46 |
| Marcell Ozuna | Orlando | 44 |
| Christian Walker | Burlington | 44 |
| Nick Senzel | Huntington Beach | 44 |
| Alex Verdugo | Detroit | 42 |
| Gio Urshela | Phoenix | 41 |
| Eloy Jimenez | Orlando | 40 |
| Maikel Franco | Clinton | 40 |
| Starling Marte | Detroit | 37 |
| Cavan Biggio | Connecticut | 37 |
| Mike Yastrzemski | Niagara Falls | 35 |
| Kyle Tucker | Burlington | 34 |
| Wilmer Flores | Niagara Falls | 33 |
| DJ LeMahieu | Phoenix | 32 |
| Brian Goodwin | Burlington | 32 |
| Corey Seager | Burlington | 31 |
| Alex Bregman | Clinton | 31 |
| David Peralta | Connecticut | 31 |