| Player | Team | SO |
|---|---|---|
| Rougned Odor | Peculiar | 216 |
| Matt Olson | Peculiar | 216 |
| Mike Trout | Peculiar | 193 |
| Javier Baez | El Paso | 182 |
| Ronald Acuna | El Paso | 180 |
| Michael Conforto | Peculiar | 180 |
| Ian Happ | Chicago | 173 |
| Victor Reyes | Milwaukee | 164 |
| Josh Bell | El Paso | 157 |
| Luke Voit | Milwaukee | 154 |
| Jeimer Candelario | Milwaukee | 153 |
| Gary Sanchez | El Paso | 151 |
| Martin Maldonado | Wisc. Rapids | 151 |
| Nick Ahmed | Peculiar | 150 |
| Jose Ramirez | Wisc. Rapids | 147 |
| Eduardo Escobar | El Paso | 145 |
| Joey Wendle | Chicago | 136 |
| Salvador Perez | Milwaukee | 134 |
| Adam Eaton | Chicago | 132 |
| Ty France | Peculiar | 130 |