| Player | Team | IP |
|---|---|---|
| Shane Bieber | Kankakee | 241.1 |
| Lance Lynn | Pea Ridge | 239 |
| Kyle Hendricks | Arizona | 235.1 |
| Yu Darvish | Boise | 231.2 |
| Gerrit Cole | Tacoma | 228.2 |
| Brandon Woodruff | Portland | 226.1 |
| Aaron Nola | Portland | 221.1 |
| Zac Gallen | Orlando | 221.1 |
| Lucas Giolito | Chicago | 217 |
| Jacob deGrom | Arizona | 212.2 |
| Luis Castillo | Dakota | 212.2 |
| Marco Gonzales | Foscoe | 211.2 |
| German Marquez | Brooklyn | 211 |
| Trevor Bauer | Ohio | 210 |
| Framber Valdez | Foscoe | 209.2 |
| Dinelson Lamet | Fraser | 207.1 |
| Antonio Senzatela | Pea Ridge | 204.2 |
| Dylan Bundy | Kansas City | 203 |
| Aaron Civale | Tacoma | 200.1 |
| Adam Wainwright | Montana | 200.1 |