| Player | Team | R |
|---|---|---|
| Kyle Freeland | Chicago | 170 |
| Trevor Williams | Chicago | 161 |
| Martin Perez | Chicago | 158 |
| Jordan Lyles | Kankakee | 156 |
| Kyle Gibson | Montana | 150 |
| Jake Odorizzi | Herefordshire | 143 |
| Patrick Corbin | Portland | 134 |
| Lance Lynn | Pea Ridge | 132 |
| Anthony DeSclafani | Tacoma | 132 |
| Gerrit Cole | Tacoma | 132 |
| Aaron Civale | Tacoma | 128 |
| Griffin Canning | Orlando | 127 |
| Kyle Hendricks | Arizona | 126 |
| Zac Gallen | Orlando | 121 |
| Blake Snell | Orlando | 120 |
| James Paxton | Ohio | 120 |
| Brett Anderson | Orlando | 118 |
| Trevor Rogers | Herefordshire | 118 |
| Dustin May | Arizona | 117 |
| Luke Weaver | Chicago | 117 |