| Player | Team | WP |
|---|---|---|
| Max Scherzer | Foscoe | 7 |
| Zac Gallen | Orlando | 6 |
| Kyle Cody | Boise | 5 |
| James Karinchak | Albuquerque | 5 |
| Sonny Gray | Tacoma | 5 |
| Rafael Dolis | Boise | 4 |
| Corbin Burnes | Brooklyn | 4 |
| Jose Berrios | Ohio | 4 |
| Kevin Gausman | Kankakee | 4 |
| Mitch Keller | Kankakee | 4 |
| Tyler Clippard | Fraser | 4 |
| Jesus Luzardo | Fraser | 3 |
| Johan Oviedo | Kankakee | 3 |
| James Paxton | Ohio | 3 |
| Blake Snell | Orlando | 3 |
| Kyle Finnegan | Orlando | 3 |
| Jake Arrieta | Albuquerque | 3 |
| Chi Chi Gonzalez | South Iowa | 3 |
| Adam Kolarek | Albuquerque | 3 |
| Framber Valdez | Foscoe | 3 |