| Player | Team | GS |
|---|---|---|
| Kyle Hendricks | Arizona | 36 |
| Kyle Freeland | Chicago | 36 |
| Marco Gonzales | Foscoe | 35 |
| Lance Lynn | Pea Ridge | 35 |
| Luis Castillo | Dakota | 35 |
| German Marquez | Brooklyn | 34 |
| Framber Valdez | Foscoe | 33 |
| Lucas Giolito | Chicago | 33 |
| Aaron Civale | Tacoma | 33 |
| Aaron Nola | Portland | 33 |
| Brandon Woodruff | Portland | 33 |
| Shane Bieber | Kankakee | 33 |
| Gerrit Cole | Tacoma | 32 |
| Jacob deGrom | Arizona | 32 |
| Martin Perez | Chicago | 31 |
| Carlos Carrasco | Foscoe | 31 |
| Max Scherzer | Foscoe | 31 |
| Jordan Lyles | Kankakee | 31 |
| Antonio Senzatela | Pea Ridge | 31 |
| Kyle Gibson | Montana | 31 |