| Player | Team | L |
|---|---|---|
| Jordan Lyles | Kankakee | 20 |
| Trevor Williams | Chicago | 20 |
| Kyle Freeland | Chicago | 19 |
| Martin Perez | Chicago | 17 |
| Aaron Civale | Tacoma | 17 |
| Kyle Gibson | Montana | 17 |
| Marco Gonzales | Foscoe | 16 |
| Kyle Hendricks | Arizona | 16 |
| Jake Odorizzi | Herefordshire | 15 |
| Anthony DeSclafani | Tacoma | 15 |
| Luke Weaver | Chicago | 15 |
| Nathan Eovaldi | Portland | 15 |
| James Paxton | Ohio | 14 |
| Dustin May | Arizona | 14 |
| Michael Wacha | Tacoma | 14 |
| Tanner Roark | Herefordshire | 14 |
| Trevor Rogers | Herefordshire | 13 |
| Mike Minor | Southland | 13 |
| Lucas Giolito | Chicago | 13 |
| Zac Gallen | Orlando | 13 |