| Player | Team | SHO |
|---|---|---|
| Shane Bieber | Kankakee | 4 |
| Corbin Burnes | Brooklyn | 4 |
| Yu Darvish | Boise | 3 |
| Lance Lynn | Pea Ridge | 2 |
| Zac Gallen | Orlando | 2 |
| Aaron Nola | Portland | 2 |
| Framber Valdez | Foscoe | 2 |
| Brad Keller | Montana | 2 |
| Zach Davies | Kansas City | 2 |
| Dinelson Lamet | Fraser | 2 |
| Brad Wieck | Fraser | 2 |
| Kenta Maeda | Fraser | 2 |
| Zack Wheeler | Fraser | 1 |
| Brady Singer | Kansas City | 1 |
| Adam Wainwright | Montana | 1 |
| Gerrit Cole | Tacoma | 1 |
| Dane Dunning | Pea Ridge | 1 |
| Drew Smyly | Tacoma | 1 |
| Taijuan Walker | Montana | 1 |
| Max Scherzer | Foscoe | 1 |