| Player | Team | H |
|---|---|---|
| Kyle Freeland | Chicago | 290 |
| Kyle Hendricks | Arizona | 288 |
| Aaron Civale | Tacoma | 269 |
| Patrick Corbin | Portland | 249 |
| German Marquez | Brooklyn | 244 |
| Antonio Senzatela | Pea Ridge | 229 |
| Zack Wheeler | Fraser | 229 |
| Martin Perez | Chicago | 223 |
| Luke Weaver | Chicago | 221 |
| Justus Sheffield | South Iowa | 217 |
| Framber Valdez | Foscoe | 212 |
| Jake Odorizzi | Herefordshire | 211 |
| Tyler Anderson | South Iowa | 211 |
| Griffin Canning | Orlando | 210 |
| Zack Greinke | Albuquerque | 207 |
| Lance Lynn | Pea Ridge | 206 |
| Marco Gonzales | Foscoe | 206 |
| Jon Lester | Southland | 206 |
| Anthony DeSclafani | Tacoma | 204 |
| Max Scherzer | Foscoe | 201 |