| Player | Team | 2B |
|---|---|---|
| Kyle Freeland | Chicago | 63 |
| German Marquez | Brooklyn | 60 |
| Kyle Hendricks | Arizona | 54 |
| Justus Sheffield | South Iowa | 53 |
| Brett Anderson | Orlando | 53 |
| Aaron Civale | Tacoma | 52 |
| Martin Perez | Chicago | 49 |
| Yu Darvish | Boise | 49 |
| Patrick Corbin | Portland | 49 |
| Antonio Senzatela | Pea Ridge | 48 |
| Michael Wacha | Tacoma | 45 |
| Luke Weaver | Chicago | 45 |
| Griffin Canning | Orlando | 45 |
| Tyler Anderson | South Iowa | 44 |
| Hyun Jin Ryu | Pea Ridge | 44 |
| Zack Wheeler | Fraser | 44 |
| Rick Porcello | Chicago | 42 |
| Zack Greinke | Albuquerque | 42 |
| Luis Castillo | Dakota | 41 |
| Lucas Giolito | Chicago | 41 |