| Player | Team | IP |
|---|---|---|
| German Marquez | Malibu | 243 |
| Kyle Hendricks | Kansas City | 231.1 |
| Lance Lynn | Riverside | 229.2 |
| Yu Darvish | Kansas City | 225.2 |
| Gerrit Cole | Guildford | 224.2 |
| Zac Gallen | California | 223 |
| Brandon Woodruff | Malibu | 221 |
| Aaron Nola | Sterling | 218.2 |
| Zack Wheeler | Las Vegas | 217 |
| Rick Porcello | New York | 216.1 |
| Antonio Senzatela | Jacksonville | 216.1 |
| Dinelson Lamet | Sterling | 211 |
| Zack Greinke | Jacksonville | 208.1 |
| Dylan Bundy | St. Louis | 208 |
| Kyle Freeland | Gallup | 207 |
| Max Scherzer | California | 206.2 |
| Shane Bieber | Jacksonville | 206 |
| Marco Gonzales | Malibu | 204.1 |
| Frankie Montas | Gallup | 203.1 |
| Jacob deGrom | Sterling | 202.2 |