| Player | Team | R |
|---|---|---|
| Kyle Freeland | Gallup | 185 |
| Zack Godley | New York | 172 |
| Patrick Corbin | Orlando | 159 |
| Rick Porcello | New York | 154 |
| Trevor Rogers | New York | 152 |
| Anibal Sanchez | New York | 147 |
| Kris Bubic | Orlando | 144 |
| Jordan Lyles | St. Louis | 143 |
| Jose Berrios | Riverside | 136 |
| Dylan Cease | Havana | 124 |
| Matthew Boyd | Gallup | 124 |
| German Marquez | Malibu | 122 |
| Asher Wojciechowski | Chicago | 121 |
| Antonio Senzatela | Jacksonville | 120 |
| Brandon Woodruff | Malibu | 119 |
| Jesus Luzardo | Las Vegas | 118 |
| Masahiro Tanaka | Las Vegas | 115 |
| Alex Cobb | Boston | 113 |
| Chris Paddack | Gallup | 110 |
| Gerrit Cole | Guildford | 110 |