| Player | Team | SO |
|---|---|---|
| Shane Bieber | Jacksonville | 338 |
| Jacob deGrom | Sterling | 336 |
| Yu Darvish | Kansas City | 335 |
| Aaron Nola | Sterling | 323 |
| Brandon Woodruff | Malibu | 314 |
| Max Scherzer | California | 303 |
| Zac Gallen | California | 298 |
| Luis Castillo | Havana | 298 |
| Trevor Bauer | Havana | 292 |
| Lucas Giolito | Las Vegas | 290 |
| Dinelson Lamet | Sterling | 286 |
| Gerrit Cole | Guildford | 285 |
| Corbin Burnes | Jacksonville | 279 |
| Carlos Carrasco | Riverside | 265 |
| Kenta Maeda | Kansas City | 251 |
| Trevor Rogers | New York | 248 |
| Dylan Bundy | St. Louis | 247 |
| Kevin Gausman | Tampa | 247 |
| Frankie Montas | Gallup | 243 |
| Sonny Gray | Malibu | 238 |