| Player | Team | SHO |
|---|---|---|
| Yu Darvish | Kansas City | 3 |
| Kenta Maeda | Kansas City | 3 |
| Shane Bieber | Jacksonville | 3 |
| Hyun Jin Ryu | Havana | 3 |
| Tanner Houck | Guildford | 2 |
| Gerrit Cole | Guildford | 2 |
| Trevor Bauer | Havana | 2 |
| Adam Wainwright | Albuquerque | 2 |
| Sonny Gray | Malibu | 2 |
| Lucas Giolito | Las Vegas | 2 |
| Brad Keller | Tampa | 2 |
| Dallas Keuchel | California | 2 |
| Brady Singer | New Jersey | 2 |
| Max Fried | New Jersey | 1 |
| Kyle Hendricks | Kansas City | 1 |
| Garrett Richards | Boston | 1 |
| Dylan Bundy | St. Louis | 1 |
| Taijuan Walker | Manhattan | 1 |
| Justin Dunn | Manhattan | 1 |
| Pablo Lopez | New York | 1 |