| Player | Team | 2B |
|---|---|---|
| Kyle Freeland | Gallup | 71 |
| Rick Porcello | New York | 61 |
| Patrick Corbin | Orlando | 55 |
| German Marquez | Malibu | 53 |
| Anibal Sanchez | New York | 51 |
| Jesus Luzardo | Las Vegas | 50 |
| Mike Fiers | New Jersey | 49 |
| Kris Bubic | Orlando | 47 |
| Ryan Yarbrough | Tampa | 47 |
| Nick Margevicius | Chicago | 45 |
| Max Scherzer | California | 45 |
| Framber Valdez | Albuquerque | 44 |
| Brett Anderson | Chicago | 44 |
| Justus Sheffield | Syracuse | 44 |
| Zack Wheeler | Las Vegas | 44 |
| Luis Castillo | Havana | 44 |
| Jon Lester | Guildford | 43 |
| Jordan Lyles | St. Louis | 43 |
| Zack Godley | New York | 43 |
| Yu Darvish | Kansas City | 42 |