| Player | Team | HR |
|---|---|---|
| Trevor Williams | Amarillo | 65 |
| Seth Lugo | Amarillo | 56 |
| Frankie Montas | Wisc. Rapids | 56 |
| Anibal Sanchez | Wisc. Rapids | 55 |
| John Means | El Paso | 54 |
| Braxton Garrett | Oak Lawn | 52 |
| Dylan Cease | Dayton | 51 |
| Mike Minor | Connecticut | 51 |
| Madison Bumgarner | El Paso | 50 |
| Aaron Nola | Burlington | 50 |
| Gerrit Cole | Burlington | 49 |
| Austin Voth | Burlington | 47 |
| Alec Mills | Monet | 47 |
| Jake Odorizzi | Amarillo | 46 |
| Asher Wojciechowski | Phoenix | 46 |
| Tanner Roark | Detroit | 45 |
| Kyle Gibson | Detroit | 43 |
| Kyle Hendricks | Connecticut | 41 |
| Ryan Castellani | Burlington | 41 |
| Cristian Javier | Orlando | 40 |