| Player | Team | IP |
|---|---|---|
| German Marquez | Clinton | 244 |
| Kyle Hendricks | Connecticut | 241 |
| Shane Bieber | Peculiar | 231.2 |
| Lance Lynn | Brooklyn | 228.2 |
| Brandon Woodruff | Dayton | 225 |
| Gerrit Cole | Burlington | 220.1 |
| Marco Gonzales | Orlando | 219 |
| Cole Hamels | Clinton | 217.2 |
| Aaron Nola | Burlington | 215.2 |
| Zack Wheeler | Brooklyn | 214.2 |
| Antonio Senzatela | El Paso | 210.1 |
| Trevor Bauer | Peculiar | 210.1 |
| Dinelson Lamet | Clinton | 208.1 |
| Framber Valdez | Brooklyn | 205 |
| Rick Porcello | Phoenix | 205 |
| Zach Davies | Clinton | 204 |
| Kenta Maeda | Monet | 203.1 |
| Kyle Freeland | Monet | 203 |
| Carlos Carrasco | Peculiar | 202.1 |
| Brady Singer | Orlando | 201 |