| Player | Team | SO |
|---|---|---|
| Shane Bieber | Peculiar | 369 |
| Trevor Bauer | Peculiar | 343 |
| Brandon Woodruff | Dayton | 305 |
| Jacob deGrom | Huntington Beach | 294 |
| Dinelson Lamet | Clinton | 293 |
| Aaron Nola | Burlington | 292 |
| Gerrit Cole | Burlington | 286 |
| Seth Lugo | Amarillo | 283 |
| Carlos Carrasco | Peculiar | 280 |
| Yu Darvish | Torrance Beach | 273 |
| Lucas Giolito | Elko | 264 |
| Kenta Maeda | Monet | 264 |
| Sonny Gray | Peculiar | 259 |
| Zac Gallen | Torrance Beach | 256 |
| Corbin Burnes | Elko | 255 |
| Zack Greinke | Wisc. Rapids | 254 |
| Zach Eflin | Chicago | 253 |
| Max Scherzer | Clinton | 242 |
| Framber Valdez | Brooklyn | 238 |
| Frankie Montas | Wisc. Rapids | 233 |