| Player | Team | L |
|---|---|---|
| Seth Lugo | Amarillo | 21 |
| Kris Bubic | Monet | 18 |
| Braxton Garrett | Oak Lawn | 18 |
| Ryan Castellani | Burlington | 18 |
| Aaron Nola | Burlington | 17 |
| Kyle Gibson | Detroit | 17 |
| Frankie Montas | Wisc. Rapids | 17 |
| Anibal Sanchez | Wisc. Rapids | 16 |
| Zack Wheeler | Brooklyn | 16 |
| Kyle Hendricks | Connecticut | 16 |
| Aaron Civale | El Paso | 15 |
| Mike Minor | Connecticut | 15 |
| Zach Eflin | Chicago | 15 |
| Ryan Yarbrough | El Paso | 14 |
| Kyle Freeland | Monet | 14 |
| Jake Arrieta | Connecticut | 14 |
| Jesus Luzardo | Huntington Beach | 14 |
| Trevor Williams | Amarillo | 14 |
| Logan Webb | Amarillo | 13 |
| Jake Odorizzi | Amarillo | 13 |