| Player | Team | SHO |
|---|---|---|
| Corbin Burnes | Elko | 3 |
| Dinelson Lamet | Clinton | 3 |
| Yu Darvish | Torrance Beach | 3 |
| Zach Davies | Clinton | 2 |
| Yusei Kikuchi | Niagara Falls | 2 |
| Brad Keller | Elko | 2 |
| Shane Bieber | Peculiar | 2 |
| Johnny Cueto | Milwaukee | 1 |
| Alex Cobb | Milwaukee | 1 |
| Trevor Bauer | Peculiar | 1 |
| Hyun Jin Ryu | Wisc. Rapids | 1 |
| Chris Bassitt | Chicago | 1 |
| Martin Perez | Chicago | 1 |
| Kenta Maeda | Monet | 1 |
| Zack Wheeler | Brooklyn | 1 |
| Framber Valdez | Brooklyn | 1 |
| Adam Wainwright | Brooklyn | 1 |
| Jaime Barria | El Paso | 1 |
| Aaron Civale | El Paso | 1 |
| Nathan Eovaldi | El Paso | 1 |