| Player | Team | H |
|---|---|---|
| German Marquez | Clinton | 283 |
| Anibal Sanchez | Wisc. Rapids | 262 |
| Rick Porcello | Phoenix | 258 |
| Kyle Freeland | Monet | 254 |
| Logan Webb | Amarillo | 253 |
| Zack Greinke | Wisc. Rapids | 238 |
| Zack Wheeler | Brooklyn | 237 |
| Aaron Civale | El Paso | 237 |
| Frankie Montas | Wisc. Rapids | 232 |
| Antonio Senzatela | El Paso | 226 |
| Kyle Hendricks | Connecticut | 225 |
| Patrick Corbin | Brooklyn | 221 |
| Seth Lugo | Amarillo | 213 |
| Trevor Williams | Amarillo | 213 |
| Jake Odorizzi | Amarillo | 209 |
| Lance Lynn | Brooklyn | 205 |
| Aaron Nola | Burlington | 205 |
| Austin Voth | Burlington | 202 |
| Ryan Yarbrough | El Paso | 196 |
| Kyle Gibson | Detroit | 195 |